Since I am related to John Howland, who came over on the Mayflower, I see Thanksgiving as something of a personal holiday. Of course, since I am also related to some of the native people who once owned these lands, I also take it personally in that way as well.
Some folks might be inclined to see the holiday as somewhat hypocritical given how the Europeans ended up dealing with the natives. While I can see the appeal in this and we should not forget the past, I think that the holiday has evolved into something that can be quite meaningful.
On the most surface level, it is about family and friends gathering to share fellowship and food. This is, obviously enough, a good thing. On a deeper level, it is a day we set aside to give thanks for all that we have and to, if we are kind, think about others. For me the most important part of my Thanksgiving is when I bring my donations to the local Turkey Trot race. Two of my friends, Brian and Judy, collect clothing and other items every year for the homeless shelter. I am thankful that I have enough that I can help those who have so much less. While in a better world everyone would have enough, it is right for those of us with more to show our appreciation by helping those who have less. To me, that is what Thanksgiving is really about: gratitude and generosity. Oh, and running.